AZD5363
4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
Capivasertib is an aminopiperidine that is piperidine substituted by 7H-pyrrolo[2,3-d]pyrimidin-4-yl, amino, and [(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]aminocarbonyl groups at positions 1, 4, and 4, respectively. It is a pan-AKT kinase inhibitor used in combination with fulvestrant for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations. It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a secondary carboxamide, a primary alcohol, a pyrrolopyrimidine, an aminopiperidine, a piperidinecarboxamide and a member of monochlorobenzenes.
Source: ChEBIDisclaimer: The information above is provided for general reference purposes only. Applications, dosage, handling procedures and suitability for any specific use must be determined solely by the user based on their own assessment. This information does not constitute a recommendation or endorsement for any particular application and should not be used as the basis for product selection.
| Catalog No. | 1143532391 |
|---|---|
| CAS Number | 1143532-39-1 |
| IUPAC Name | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
| Purity | 98% |
| SMILES | C(=O)(N[C@@H](CCO)c1ccc(cc1)Cl)C1(N)CCN(CC1)c1c2c(ncn1)[nH]cc2 |
Certificate of Analysis (COA)
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Safety Data Sheet (SDS)
GHS-compliant safety information including hazards, handling, and disposal.
This product is not classified as a hazardous material under standard shipping regulations.
For complete safety information, always refer to the product's Safety Data Sheet.